MK-677, also known as Ibutamoren, is a non-peptidic growth hormone secretagogue that functions as a ghrelin receptor agonist. It mimics the action of ghrelin to stimulate the pituitary gland, promoting the natural secretion of growth hormone and subsequently increasing circulating levels of IGF-1.

Research involving MK-677 has focused on its potential to improve muscle mass, enhance recovery, and support fat metabolism without suppressing endogenous hormone production. It has been studied in both healthy individuals and those with GH deficiencies for its ability to maintain elevated GH levels over extended periods. Additional areas of interest include bone mineral density, sleep quality, and overall metabolic health. Due to its oral bioavailability and long half-life, MK-677 is considered a practical alternative to injectable GH-releasing therapies in experimental settings.