Exemestane is an irreversible steroidal aromatase inhibitor (also known as a suicide inhibitor) that works by permanently inactivating the aromatase enzyme, which is responsible for the conversion of androgens into estrogens. This mechanism leads to a significant reduction in circulating estrogen levels, making it a focus of studies involving estrogen suppression.

Exemestane has been widely researched in contexts such as hormone-sensitive conditions, endocrine regulation, and post-cycle therapy to mitigate the effects of excess estrogen. Unlike non-steroidal aromatase inhibitors, exemestane has a steroidal structure, which allows it to bind more effectively to the enzyme’s active site. Studies have also explored its impact on bone density, lipid metabolism, and its role in restoring hormonal balance following the use of anabolic agents.

Storage: At 59-77°F (15-25°C).
Protect from direct heat, sunlight and moisture.
Do not freeze.